Care for Patients in the ED with Confidence
Sepsis Poses Clinical and Operational Challenges
for Nurses in the ED
high patient volume
1/5 Patients
Who present to the ED are potentially septic, requiring significant evaluation and slowing throughput1
pressure to accurately risk stratify patients at triage
59%
Current triage accuracy rate in the ED, which is largely attributed to under-triage leading to delays in critical care and worse outcomes2
increasing emphasis on
meeting metrics
SEP-1
The push for early intervention with the SEP-1 metric can result in overtreatment and excess utilization of nursing resources3
alert fatigue
85 – 99%
Percent of alerts that are non-actionable, leading to desensitization, increasing missed critical alarms, and driving burnout4
- Wang HE, Jones AR, Donnelly JP. Revised national estimates of emergency department visits for sepsis in the United States. Crit Care Med. 2017;45:1443-1449.
- ENA. New Triage Workshop Focuses on Improved Triage Accuracy. 2024.
- CMS. FY 2024 IPPS and Long-Term Care Hospital Final Rule. Published August 1, 2024.
- Benincasa, C et al. Alarm Fatigue Reduction in a Single Patient Room Neonatal Intensive Care Unit. Online J of Iss in Nurs. 2024;29(2).
All results should be interpreted in the context of the other clinical observations and laboratory test results
IntelliSep Now Offers Early Sepsis Detection with Clear, Actionable Results
IntelliSep is a diagnostic tool that risk-stratifies patients based on their probability of having sepsis, providing results in about 8 minutes so you can deliver the right care to the right patient at the right time.
IntelliSep is an FDA-cleared in vitro diagnostic test for adult patients with signs and symptoms of infection who present to the Emergency Department
Application of Early Sepsis Detection Begins in Triage
Incorporating the IntelliSep sepsis test into your ED workflow at the time of triage provides a more reliable, objective measure for identifying patients’ risk of sepsis, leading to more accurate and timely diagnosis and treatment.
*The above decision-making notes are based on one site’s institutional practices and validation of IntelliSep. See the IntelliSep Test Instructions for Use for all cleared claims and performance data.
- O’Neal et al. Pooled analysis. Presented at AEM; 2024.
Expected Impact of IntelliSep
improve efficiency
Detect sepsis earlier, faster, and more accurately, enabling more efficient resource allocation and shorter ED wait times1
empower early sepsis detection
Gain insight into patients’ state of immune activation so the care team can intervene in a timely manner with life-saving treatment
focus on patient-centered care
Confidently rule out sepsis mimics, reducing inappropriate care and improving antimicrobial stewardship2
achieve clinical excellence
Deliver actionable alerts with automated workflows that help nurses identify critically ill patients and prioritize their care
- T Jagneaux, et. al. Expediting Identification of Occult Sepsis with a Novel Diagnostic for Patients Presenting to the ED with Possible Infection. Presented at Association for Diagnostics and Laboratory Medicine (ADLM); 2024.
- Thomas CT et al. Evaluation of early-stage implementation results of a cellular host-response test in an emergency department setting. Presented at ESCMID; April 2024; Barcelona, Spain.
The Patient Experience
“The IntelliSep test helped to identify my sepsis early, leading to immediate and necessary treatment. I believe the test was crucial in saving my life. I can’t speak highly enough of the test – and I can’t imagine a hospital not having it.”
TERRI WHITE
PATIENT, OUR LADY OF THE LAKE REGIONAL MEDICAL CENTER
IntelliSep Early Impact at an 900+ bed Regional Medical Center
1.28
Reduction in LOS of patients with ISI ordered1
15%
Reduction in antibiotics administered to patients with ISI ordered2
19%
Reduction in blood cultures ordered for patients with ISI ordered2
80%
Reduction in overhead sepsis alerts per day3
- Thomas CT et al. Fiscal impact of a rapid sepsis diagnostic in the ED. Presented at ISICEM; March 19, 2024; Brussels, Belgium. Presented by Hollis O’Neal Jr., MD, MSc.
- Thomas CT et al. Evaluation of early-stage implementation results of a cellular host-response test in an emergency department setting. Presented at ESCMID; April 2024; Barcelona, Spain.
- Cytovale. IntelliSep Site Experience. Case study with Our Lady of the Lake Regional Medical Center. 2023. [MKG 0148].
From Test to Treatment: Clinical Interpretation, Rationale, and Impact of the IntelliSep Sepsis Test
Case Study
Our Lady of the Lake
Regional Medical Center
IntelliSep has been seamlessly integrated into clinical workflows at Our Lady of the Lake Regional Medical Center. It has improved triage for patients with suspected sepsis, reducing time to diagnosis, and allowing for more efficient use of antibiotics and blood cultures, thereby optimizing resource utilization. These streamlined processes and care pathways have resulted in substantial clinical benefit as well as cost savings. This document presents a detailed exploration of Our Lady of the Lake Regional Medical Center’s strategy to address sepsis in the ED, improve triage, and develop an effective clinical interpretation and application of the test.