Cutting through the Clinical Uncertainty by Observing Immune Activation
Sepsis is a Medical Emergency that is Common, Costly, and Difficult to Diagnose
Misdiagnosis and delayed treatment may lead to serious consequences for patients and hospitals.
80% of sepsis deaths could be prevented with rapid, targeted, predictive testing4
- AHRQ. Most Expensive Hospital Conditions, 2017. Available at: https://www.hcup-us.ahrq.gov/reports/statbriefs/sb261-Most-Expensive-Hospital-Conditions-2017.jsp.
- Wang HE, Jones AR, Donnelly JP. Revised national estimates of emergency department visits for sepsis in the United States. Crit Care Med. 2017;45:1443-1449.
- Gaddis ML, Gaddis GM. Detecting sepsis in an emergency department: SIRS vs. qSOFA. Mo Med. 2021 May-Jun;118(3):253-258. PMID: 34149086.
- Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34(6):1589-1596.
Unlike Other Time-Sensitive Medical Emergencies, Sepsis Lacked a Highly Sensitive Detection Tool.
Until Now.
Like heart attack and stroke, there is now an objective detection tool for sepsis, supporting rapid identification and treatment.
Kumar A et al. Duration of hypotension prior to initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Critical Care Medicine. 2006;(34):1589-1596.
Now You Can Identify which Patients are at Risk of Developing Sepsis during ED Triage
IntelliSep Offers Early Sepsis Detection with Clear, Actionable Results
In about 8 minutes IntelliSep delivers clinically actionable results, risk-stratifying patients based on their probability of having sepsis.
Results are presented as a numerical value between 0.1 and 10.0, which is further stratified into 3 discrete bands.
IntelliSep helps the ED accelerate the time to diagnosis and treatment, patient disposition, and throughput.
*All results should be interpreted in the context of the other clinical observations and laboratory test results for the patient
Pathogen-Agnostic
Host response approach covers all pathogens
Fits ED and Lab Workflows
100uL from a standard ‘purple-top’ K2 EDTA blood collection tube
Rapid Results
~ 8 minutes blood-to-score time
Diagnostic Confidence
Sepsis probability score extends out to 3 days
Seamless Information Communication
Results automatically delivered to LIS at the end of each run
Performance Highlights
- 1,002 adult patients with signs or suspicion of infection presenting to the ED, spanning 5 adult cohorts from separate observational studies
- Performance was compared to retrospective physician adjudication of sepsis blinded to the IntelliSep results.
- Zero 30-day in-hospital sepsis-associated mortality in Band 1 patients
- Diagnostic performance provides confidence for the next 3 days
IntelliSep is a reliable tool for rapid diagnosis and risk stratification for sepsis in patients who present to the ED with signs and suspicion of infection
O’Neal HR et al. Pooled analysis. Presented at: Academic Emergency Medicine Annual Meeting; 2024.
Application of Early Sepsis Detection Begins in Triage
Incorporating the IntelliSep test into your ED workflow will provide a reliable, objective measure for identifying patients’ risk of sepsis, leading to more accurate and timely diagnosis and treatment.
*The above decision-making notes are based on one site’s institutional practices and validation of IntelliSep. See the IntelliSep Test Instructions for Use for all cleared claims and performance data.
1. O’Neal HR et al. Pooled analysis. Presented at: Academic Emergency Medicine Annual Meeting; 2024.