Getting the Right Care to the Right Patient at the Right Time
Sepsis Poses Clinical and Operational Challenges for Providers
high patient volume
1/5 patients
Who present to the ED are potentially septic, requiring significant evaluation and slowing throughput1
non-specific presentation
Up to 21%
Of patients who experience sepsis have a delayed or misdiagnosis2
insufficient tools
78.1 – 93.0
Range in NPV for sepsis from blood cultures, lactate, and procalcitonin3
growing physician burnout
62%
Of ED physicians report experiencing burnout4
- Wang HE, Jones AR, Donnelly JP. Revised national estimates of emergency department visits for sepsis in the United States. Crit Care Med. 2017;45:1443-1449.
- Neilson HK, Dobranowski J, Baxter S, et al. Diagnostic delays in sepsis: Lessons learned from a retrospective study of Canadian medico-legal claims. Crit Care Explor. 2023;5(2).
- O’Neal, et al. Assessment of a Cellular Host Response Test as a Sepsis Diagnostic for Those With Suspected Infection in the Emergency Department. Crit Care Explor. 2021;3(6).
- American Medical Association. These 6 physician specialties have the most burnout. AMA. 2023. https://ama-assn.org/practice-management/physician-health/these-6-physician-specialties-have-most-burnout.
All results should be interpreted in the context of the other clinical observations and laboratory test results for the patient
IntelliSep Now Offers Early Sepsis Detection with Clear, Actionable Results
IntelliSep is a diagnostic tool that risk-stratifies patients based on their probability of developing sepsis within 3 days post-testing. IntelliSep delivers results in about 8 minutes, enabling care teams to provide faster, more personalized care.
IntelliSep is an FDA-cleared in vitro diagnostic test for adult patients with signs and symptoms of infection who present to the Emergency Department
Application of Early Sepsis Detection Begins in Triage
Incorporating the IntelliSep sepsis test into your ED workflow at the time of triage provides a more reliable, objective measure for identifying patients’ risk of sepsis, leading to more accurate and timely diagnosis and treatment.
*The above decision-making notes are based on one site’s institutional practices and validation of IntelliSep. See the IntelliSep Test Instructions for Use for all cleared claims and performance data.
- O’Neal et al. Pooled analysis. Presented at: Academic Emergency Medicine Annual Meeting (AEM); 2024.
Expected Impact of IntelliSep
increase operational efficiency
Expedite diagnoses1 and disposition decisions, leading to more efficient resource allocation, shorter ED wait times, decreased boarding, and optimized bed usage2
deliver patient-centered care
Provide the right treatment to the right patients, leading to improved antimicrobial stewardship and shorter length of stay, while complying with SEP-1 guidelines3
early and accurate detection
Deliver sepsis care to appropriate patients or confidently rule out sepsis and focus on evaluation for other critical illnesses
IntelliSep NPV: 98% – See more data
improve clinician satisfaction
Empower clinicians to identify and prioritize critically ill patients with confidence, contributing to less burnout, stronger teamwork, and improved retention
- T Jagneaux, et. al. Expediting Identification of Occult Sepsis with a Novel Diagnostic for Patients Presenting to the ED with Possible Infection. Presented at Association for Diagnostics and Laboratory Medicine (ADLM); 2024.
- Our Lady of the Lake Regional Medical Center. From Test to Treatment: Clinical Interpretation, Rationale, and Impact of the IntelliSep Test. Case study. 2024.
- Thomas CT et al. Fiscal impact of a rapid sepsis diagnostic in the ED. Presented at ISICEM; March 19, 2024; Brussels, Belgium. Presented by Hollis O’Neal Jr., MD, MSc.
IntelliSep Early Impact at a 900+ Bed Regional Medical Center
1.28
Reduction in LOS of patients with ISI ordered1
15%
Reduction in antibiotics administered to patients with ISI ordered2
19%
Reduction in blood cultures ordered for patients with ISI ordered2
80%
Reduction in overhead sepsis alerts per day3
“The IntelliSep test helped to identify my sepsis early, leading to immediate and necessary treatment. I believe the test was crucial in saving my life. I can’t speak highly enough of the test—and I can’t imagine a hospital not having it.”
- Thomas CT et al. Fiscal impact of a rapid sepsis diagnostic in the ED. Presented at ISICEM; March 19, 2024; Brussels, Belgium. Presented by Hollis O’Neal Jr., MD, MSc.
- Thomas CT et al. Evaluation of early-stage implementation results of a cellular host-response test in an emergency department setting. Presented at ESCMID; April 2024; Barcelona, Spain.
- Cytovale. IntelliSep Site Experience. Case study with Our Lady of the Lake Regional Medical Center. 2023. [MKG 0148].
From Test to Treatment: Clinical Interpretation, Rationale, and Impact of the IntelliSep Sepsis Test
Case Study
Our Lady of the Lake
Regional Medical Center
IntelliSep has been seamlessly integrated into clinical workflows at Our Lady of the Lake Regional Medical Center. It has improved triage for patients with suspected sepsis, reducing time to diagnosis, and allowing for more efficient use of antibiotics and blood cultures, thereby optimizing resource utilization. These streamlined processes and care pathways have resulted in substantial clinical benefit as well as cost savings. This document presents a detailed exploration of Our Lady of the Lake Regional Medical Center’s strategy to address sepsis in the ED, improve triage, and develop an effective clinical interpretation and application of the test.