A Novel Approach to
Sepsis is a Driver of Operational, Financial and Clinical Concerns for Hospitals
MAJORITY OF HOSPITALS EXPERIENCE ED OVERCROWDING
90%
Of EDs experience overcrowding, leading to increased patient wait times, higher rates of patients leaving without being seen, and significant delays in care1
COST BURDEN DUE TO SLOW ED THROUGHPUT
$500
Lost revenue to the ED per patient who leaves without being seen2
SEPSIS – A FREQUENTLY MISDIAGNOSED CONDITION
Top 5
Sepsis is one of the top 5 diseases responsible for all diagnostic-related deaths and disabilities3
Increasing REGULATORY REQUIREMENTS
SEP-1
Meeting CMS’ SEP-1 requirements can strain administrative and clinical resources. Metric penalties add pressure to achieve compliance, while maintaining high standard of care.4
- Farley et al. Emergency Department Crowding: High Impact Solutions. ACEP Emergency Medicine Practice Committee. 2016.
- Becker’s Hospital CFO Report. What is the Financial Impact of Losing 5 ED Patients Per Day? Blog Post. 2012.
- End Sepsis. Sepsis is a Leader in Misdiagnosis-Related Deaths. https://www.endsepsis.org/2023/07/18/sepsis-a-leading-cause-of-misdiagnosis-related-deaths-and-disabilities/.
- CMS. FY 2024 IPPS and Long-Term Care Hospital Final Rule. Published August 1, 2024.
IntelliSep Brings Necessary Protocolization to Sepsis
We have witnessed the power of protocolized care with diagnostic tools across many severe medical conditions. Similarly, using IntelliSep in protocolized sepsis screening may offer benefits to potentially septic patients.
IntelliSep Supports Rapid Sepsis Detection with Exponential Impact on Downstream Care, Quality and Costs
Expected Impact of IntelliSep
enhanced ed efficiency
Enable rapid patient risk stratification to support efficient triage along with early and accurate diagnoses.
improve the patient experience while reducing costs
Reduce non-beneficial care, increase speed-to-treatment, and shorten LOS to lower total costs1
optimize clinical operations
Minimize unnecessary tests and reduce sepsis alerts, improving overall workload2
standardize clinical practice and improve patient outcomes
Minimize bias and reduce variation in clinical decision-making, while meeting SEP-1 measures aligned with patient-centric care
- Thomas CT et al. Fiscal impact of a rapid sepsis diagnostic in the ED. Presented at ISICEM; March 19, 2024; Brussels, Belgium. Presented by Hollis O’Neal Jr., MD, MSc.
- Cytovale. IntelliSep Site Experience. Case study with Our Lady of the Lake Regional Medical Center. 2023. [MKG 0148].
IntelliSep Early Impact at an 900+ bed Regional Medical Center
39%
Relative risk reduction in 30-day sepsis associated
mortality rate1
40%
Reduction in blood cultures among low-risk Band 1 patients1
0.76
Reduction in
average LOS for
sepsis patients1
$2,235
Estimated cost savings per sepsis patient due to reduction in LOS2,3
- Thomas CB, Wyler B, D’Antonio CM, Laperouse M, et al. Impact of a Sepsis Quality Improvement Initiative on Clinical and Operational Outcomes. Healthcare. 2025; 13(11):1273.
- AHRQ Report to Congress: An Assessment of Sepsis in the United States and its Burden on Hospital Care (2023)
- Assuming average $2,941 cost per inpatient day; $25,000 per sepsis admission and LOS of 8.5 days
From Test to Treatment: Clinical Interpretation, Rationale, and Impact of the IntelliSep Sepsis Test
Real-World Results
Our Lady of the Lake
Regional Medical Center
IntelliSep has been seamlessly integrated into clinical workflows at Our Lady of the Lake Regional Medical Center. It has improved triage for patients with suspected sepsis, reducing time to diagnosis, and allowing for more efficient use of antibiotics and blood cultures, thereby optimizing resource utilization. These streamlined processes and care pathways have resulted in substantial clinical benefit as well as cost savings. This document presents a detailed exploration of Our Lady of the Lake Regional Medical Center’s strategy to address sepsis in the ED, improve triage, and develop an effective clinical interpretation and application of the test.