Saving Lives with Rapid,
Real-World Impact
After six months of using IntelliSep, our results show that a higher percentage of patients are returning home to their families earlier, at lower cost for them and the hospital. Our ability to improve patient flow has been revolutionary.”
Dr. Christopher Thomas
Chief Quality Officer Franciscan Missionaries of Our Lady Health System
IntelliSep: One Site’s Experience
Relative risk reduction in 30-day sepsis associated mortality rate
Reduction in blood cultures
Increase in blood cultures among high-risk Band 3 patients
Reduction in average LOS per ICU in-patient
Estimated cost savings per sepsis patient due to reduction in LOS
Reduction in Code Sepsis alerts from 30 to 6 per day
Increased speed-to-bed for Band 3 patients compared to Band 1 patients, enabled by IntelliSep and Code Sepsis protocol
Increase in SEP-1 compliance while
reducing use of resources
The above Impact Notes regarding IntelliSep were generated by the Emergency Department of an 900-Bed Regional Medical Center over a 90-day period and were based on their institutional practices and site validation of IntelliSep.
See the IntelliSep Test Instructions for Use for all cleared claims and performance data.
- Thomas CB, Wyler B, D’Antonio CM, Laperouse M, et al. Impact of a Sepsis Quality Improvement Initiative on Clinical and Operational Outcomes.Healthcare. 2025; 13(11):1273.
- AHRQ Report to Congress: An Assessment of Sepsis in the United States and its Burden on Hospital Care (2023)
- Assuming average $2,941 cost per inpatient day; $25,000 per sepsis admission and LOS of 8.5 days
- Cytovale. IntelliSep Site Experience. Case study with Our Lady of the Lake Regional Medical Center. 2023. [MKG 0148].
- Cytovale. From Test to Treatment: Clinical Interpretation, Rationale, and Impact of the IntelliSep Test. 2024.
- Thomas CB, Richard K, Grantham A, Jagneaux T, Sorrells M, O’Neal H. Investigation of the Effect of Implementing a Host Response Test on SEP-1 Compliance. Presented at: ACEP Scientific Assembly; 2025 Oct; Salt Lake City, UT.
From Test to Treatment: Clinical Interpretation, Rationale, and Impact of the IntelliSep Sepsis Test
Real-World Results
Our Lady of the Lake
Regional Medical Center
IntelliSep has been seamlessly integrated into clinical workflows at Our Lady of the Lake Regional Medical Center. It has improved triage for patients with suspected sepsis, reducing time to diagnosis, and allowing for more efficient use of antibiotics and blood cultures, thereby optimizing resource utilization. These streamlined processes and care pathways have resulted in substantial clinical benefit as well as cost savings. This document presents a detailed exploration of Our Lady of the Lake Regional Medical Center’s strategy to address sepsis in the ED, improve triage, and develop an effective clinical interpretation and application of the test.